Patient Toxicology

Toxicology Panels

Patients Choice Laboratories™ (PCL) in Indianapolis, IN provides confirmatory drug testing with Liquid Chromatography-Mass Spectrometry (LC-MS), the gold standard in clinical toxicology drug testing. LC-MS provides highly sensitive and precise testing to confirm positive results from toxicology drug screening with immunoassays or in-clinic dipstick screens. This service will help you provide unbiased, third party support for your patients to ensure they are benefiting as much as possible from their medication regimens.

Confirmatory drug testing with LC-MS provides additional information to supplement screening results. Screening tests detect drugs by class; however, it is unable to determine the specific drug that is present in the sample. For example, a sample may be positive on a screening test for opiates, but the screen is incapable of defining the specific drug present in the specimen. LC-MS testing provides confirmation of positive samples and additionally identifies the specific drug(s) present.

PCL’s toxicology report is provided to you in a format that is easy to read and color-coded for quick interpretation. The turn-around time for confirmatory testing is 24 to 72 hours from sample receipt. Your patient’s results will be delivered to you in a HIPAA-compliant online portal.

Tests may be ordered by drug class or as a comprehensive panel. All testing has been extensively validated in-house by experienced clinical scientists. PCL is CLIA and COLA accredited and registered with the College of American Pathologists (CAP) for accreditation, which will be completed by 2016.

PCL provides quality, accurate confirmatory testing for a number of physicians and other health care professionals, including:
  • Private doctor’s offices and clinics
  • Pain management clinics
  • Mental health clinics
  • Cardiac clinics
  • Substance abuse clinics and organizations

Our laboratory is continuously validating additional drugs to expand our toxicology test menu to offer you the most comprehensive drug testing to best support your patients. Currently, the following drugs are validated and available for testing:


Drug Classes Drugs and Metabolites Detected
Amphetamines Amphetamines, Methamphetamine, MDA, MDEA, MDMA
Barbiturates Amobarbital/Pentobarbital, Butalbital, Phenobarbital, Secobarbital
Benzodiazepines Alprazolam, Hydroxyalprazolam, Clonazepam, 7-Aminoclonazipam, Diazepam, Nordiazepam, Flunitrazepam, Flurazepam, Lorazepam, Midazolam, Oxazepam, Temazepam
Buprenorphine Buprenorphine, Norbuprenorphine
Cannabinoids THC-COOH
Carisoprodol Carsioprodol, Meprobamate
Cocaine Benzoylecgonine
Dextromethorphan Dextromethorphan, Dextrorphan
Ethyl Glucuronide Ethyl Glucuronide (EtG), Ethyl Sulfate (EtS)
Fentanyl Fentanyl, Norfentanyl
Ketamine Ketamine, Norketamine
Meperidine Meperidine, Normeperidine
Methadone Methadone, EDDP
Opiates Codeine, Hydrocodone, Hydromorphone, Morphine, Norhydrocodone, Noroxycodone, Oxycodone, Oxymorphone
Ritalin Methylphenidate, Ritalinic Acid
Tricyclic Antidepressants Amitriptyline, Desipramine, Imipramine, Nortriptyline
Zolpidem Zolpidem, Zolpidem 6-Carboxylic Acid, Zolpidem Phenyl-4-Carboxylic Acid
For more information about ordering confirmatory testing, please contact a PCL Client Services Representative at (317) 299-5227.

References:  J Addict Dis.2010 Oct;29(4):436-48.  |  Center for Substance Abuse Treatment. Improving Treatment for Drug-Exposed Infants. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 1993. (Treatment Improvement Protocol (TIP) Series, No. 5.) Appendix C – Urine toxicology Guidelines.Available from: